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The second set of palexia two Phase II studies used a fixed dose titration design with an initial two weeks of forced titration followed by two weeks on a stable dose .
The Phase III development program for tapentadol SR was based on a combination of efficacy studies with controlled dose adjustment palexia 50 mg filmtabletten tapentadol mexico nucynta vs dilaudid tapentadol bijwerkingen nucynta (PAI-3008/KF11, PAI-3009/KF12, and PAI-3011/KF23) and a study with a fixed dose maintenance design (PAI-3015/KF36), all using twice daily dosing .
The palexia pain conditions (listed above) were chosen because they usually present with moderate to severe pain which is often treated with opioids .
Phase II and Phase III palexia studies evaluating the efficacy of tapentadol SR are summarised in Table 11 .
AusPAR Palexia palexia SR Tapentadol CSL Ltd PM-2009-02489-3-1 Final 28 February 2011 Page 36 of 126 Table 11: Overview of Study Designs of Phase II/ III Tapentadol SR Chronic Pain Studies The initial evidence for efficacy of tapentadol was obtained using an oral tapentadol IR formulation as well as from IV administration in the initial Phase II studies of acute pain conditions .
Following the development of tapentadol or tramadol tapentadol sr australia tapentadol zulassung nucynta an opioid tapentadol a tapentadol SR formulation, two placebo-and active-controlled Phase II studies employing doses of tapentadol SR up to 86 mg twice daily in subjects with chronic pain were performed .
tapentadol yantil nucynta recreational tapentadol radar nucynta vs methadone order palexia 50 One study was performed in subjects with chronic pain due to osteoarthritis (KF09), and one study in subjects with chronic low back pain (KF10) .
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